Project Proposal
Seeking international collaborators for upcoming calls - Predictive Medicine Group from Spain
Can act as:
Seeking expertise:
FIBAO - Foundation for Biomedical Research in Eastern Andalusia Alejandro Otero
FIBAO is a non-profit foundation specializing in the management of biomedical research for the Andalusian Public Health System. The foundation supports biomedical research groups and facilitates the transfer of research results to industry and society. FIBAO offers a comprehensive platform of services covering the entire value chain of biomedical research, from discovery to application in healthcare.
Key Facts:
• Institutes Managed: iBS.Granada Research Centre, Hospitals in Eastern Andalusia.
• Researchers and Patients: FIBAO hosts around 500 researchers and provides services to approximately 8,000 patients annually through its associated hospitals and research centres.
• Management expertise: wide experience in managing research projects and organization and management of clinical trials.
We present the group from Preventive Medicine.
Research Group Expertise:
Our research group has expertise in Preventive Medicine and Public Health, especially in the prevention and control of infectious diseases. Our research topics have been focused on two main lines:
(1) Immunization of individuals with or at risk of immunosuppression; patients under immunosuppressive treatments, including biologics (e.g., monoclonal antibodies), HSC or solid organ transplant recipients, HIV, cancer under chemotherapy, splenectomy and other immunosuppressive conditions. We are interested in understanding the mechanisms implied in the immune response to vaccination of this patients (e.g., choosing the best diagnostic tests to evaluate such response, or study how this diagnostic tests are associated with clinical outcomes), how specific immunosuppressive treatments affects the immune response to certain vaccines, and how health promotion and the use of improved vaccines (e.g., adjuvanted, high-dose or specific vaccine schedules) can help improve the immune response to vaccination. We have published works regarding influenza, pneumococcal, hepatitis B, meningococcal, herpes zoster and COVID-19 vaccination, and we have developed a clinical guideline regarding vaccination of patients under immunosuppressive biological treatments.
(2) Surveillance and control of multi-drug resistant bacteria (MDRB); we are interested in developing strategies to improve the early detection of hospitalised patients colonized by MDRB (especially the most vulnerable groups such as patients living in long-term care facilities or with fragility) and the control of such patients in healthcare centres to prevent MDRB transmission. We have published several articles on the epidemiology of MDRB in our medium and the early detection of patients in high-risk settings (e.g., internal medicine services and long-term care facilities).
Possible Involvement in the project:
- Patient recruitment: immunocompromised adults that require immunization.
- Patient recruitment: hospitalized adults at risk of MDRB colonization.
- Patient recruitment: healthcare professionals of our centre.
- Implementation of health promotion strategies in immunocompromised patients attending outpatient consultations (e.g., vaccination counseling, preventive measures, adherence support).
- Clinical analysis: tests conducted as part of the standard practice (e.g., serology after HBV vaccination, colonization swabs during ICU admission, etc.) or data obtained through clinical records or patient interviews.
- Data analysis. We have expertise in conventional statistical analyses (e.g., survival analysis, multivariable regression models, ecological analyses using maps, multiple imputation, etc.) but also in causal analysis (causal approaches in observational studies using DAGs, inverse-probability weighting IPW, and other specific techniques and designs to approach explicative causal associations) using R or Stata software.
Interested in participating in international projects.
Please contact: [email protected]