Open Innovation Opportunity

Project Proposal

The available expertise spans a highly interdisciplinary framework addressing sex- and gender-specific mechanisms of cardiovascular disease across the lifespan. It includes advanced clinical cardio-obstetrics research on hypertensive disorders of pregnancy, vascular aging, and non-invasive vascular phenotyping combined with biomarker discovery. Forensic medicine contributes unique post-mortem cardiovascular, toxicological, environmental, and genomic analyses to identify sex-specific determinants of sudden cardiac death and disease mechanisms. Experimental cell biology provides state-of-the-art 2D and 3D vascular models, stem cell technologies, biomaterials, and molecular and ultrastructural analyses. Zebrafish genetic models enable in vivo investigation of sex- and hormone-dependent cardiovascular development, pathology, and regeneration. Large-animal (porcine) preclinical platforms support translational cardiovascular surgery, ECMO/ECC models, and interventional training. Neuroscience expertise addresses autonomic and thermoregulatory control of cardiovascular function in pathological states. Machine learning and geometric deep learning methods support multimodal biomedical data analysis, imaging, and personalized risk modelling. Nutritional science and preventive cardiology contribute population studies, nutraceutical development, and lifestyle interventions. Together, these competencies form a comprehensive ecosystem for Horizon-level research on sex- and gender-specific cardiovascular risk factors, mechanisms, and interventions.

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